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Hoffmann-La Roche Ltd., Teva Pharmaceutical Industries Ltd., GlaxoSmithKline plc, and Sandoz International GmbH

However, unlike the non-cleavable probe, the cell-impermeant reducing agent Mesna can be used to un-label residual surface receptors, as previously described using non-lanthanide SNAP-probes (Buenaventura et al., 2018), so that fluorescent signal originates exclusively from internal receptors endocytosed during a prior agonist treatment step (see Supplementary Figure 2E, 2F for optimisation of Mesna cleavage)

Your medical chart must reflect the diagnosis

Kwakkel, J